On Thu, Aug 26, 2021 at 12:57:14PM -0400, post...@ptld.com wrote:

> NOQUEUE: reject: RCPT from unknown[196.188.245.169]: 550 5.1.0 
> <u...@example.com>: Sender address rejected: User unknown in virtual 
> mailbox table; from=<u...@example.com> to=<u...@example.com> proto=ESMTP 
> helo=<[196.188.245.169]>

The built-in defaults are:

    smtpd_reject_unlisted_recipient = yes
    smtpd_reject_unlisted_sender = no

> In that case is postfix rejecting based on the From: or the To: not 
> being a valid user?

The log message says "Sender address rejected".

> Why is postfix checking either when smtpd_reject_unlisted_recipient = 
> no?

Perhaps you have "smtpd_reject_unlisted_sender = yes"?

-- 
    Viktor.

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