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________________________________
 From: Bukan Pedanda <[email protected]>
To: [email protected] 
Sent: Wednesday, May 15, 2013 10:13 AM
Subject: [proletar] BBC: Embryonic stem cells: Advance in medical human cloning
 


  

FYI

BBC News Health

15 May 2013 Last updated at 16:00 GMT

Embryonic stem cells: Advance in medical human cloning
By James Gallagher Health and science reporter, BBC News

Human cloning has been used to produce early embryos, marking a "significant 
step" for medicine, say US scientists.

The cloned embryos were used as a source of stem cells, which can make new 
heart muscle, bone, brain tissue or any other type of cell in the body.

The study, published in the journal Cell, used methods like those that produced 
Dolly the sheep in the UK.

However, researchers say other sources of stem cells may be easier, cheaper and 
less controversial.

Stem cells are one of the great hopes for medicine. Being able to create new 
tissue might be able to heal the damage caused by a heart attack or repair a 
severed spinal cord.

There are already trials taking place using stem cells taken from donated 
embryos to restore people's sight.

However, these donated cells do not match the patient so they would be rejected 
by the body. Cloning bypasses this problem.

The technique used - somatic cell nuclear transfer - has been well-known since 
Dolly the sheep became the first mammal to be cloned, in 1996.

Skin cells were taken from an adult and the genetic information was placed 
inside a donor egg which had been stripped of its own DNA. Electricity was used 
to encourage the egg to develop into an embryo.

However, researchers have struggled to reproduce the feat in people. The egg 
does start dividing, but never goes past the 6-12 cell stage.
'Real deal'

A South Korean scientist, Hwang Woo-suk, did claim to have created stem cells 
from cloned human embryos, but was found to have faked the evidence.

Now a team at the Oregon Health and Science University have developed the 
embryo to the blastocyst stage - around 150 cells - which is enough to provide 
a source of embryonic stem cells.

Dr Shoukhrat Mitalipov said: "A thorough examination of the stem cells derived 
through this technique demonstrated their ability to convert just like normal 
embryonic stem cells, into several different cell types, including nerve cells, 
liver cells and heart cells.

"While there is much work to be done in developing safe and effective stem cell 
treatments, we believe this is a significant step forward in developing the 
cells that could be used in regenerative medicine."

Chris Mason, a professor of regenerative medicine at University College London, 
said this looked like "the real deal".

"They've done the same as the Wright brothers really. They've looked around at 
where are all the best bits of how to do this from different groups all over 
the place and basically amalgamated it.

"The Wright brothers took off and this has actually managed to make embryonic 
stem cells."
The ethical rival

Embryonic stem cell research has repeatedly raised ethical concerns and human 
eggs are a scarce resource. This has led researchers to an alternative route to 
stem cells.

The technique takes the same sample of skin cells but converts them using 
proteins to "induced pluripotent" stem cells.

However, there are still questions about the quality of stem cells produced 
using this method compared with embryonic stem cells.

Prof Mason said the field was leaning towards induced pluripotent stem cells: 
"It has got a lot of momentum behind it, a lot of funding and a lot of powerful 
people now."

Dr Lyle Armstrong at Newcastle University said that the study "without doubt" 
marked an advance for the field.

But he warned: "Ultimately, the costs of somatic cell nuclear transfer-based 
methods for making stem cells could be prohibitive."

Dr David King, from the campaign group Human Genetics Alert, warned that: 
"Scientists have finally delivered the baby that would-be human cloners have 
been waiting for: a method for reliably creating cloned human embryos.

"This makes it imperative that we create an international legal ban on human 
cloning before any more research like this takes place. It is irresponsible in 
the extreme to have published this research."

BBC © 2013 The BBC is not responsible for the content of external sites. Read 
more.


 

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