http://edition.cnn.com/2013/08/08/health/malaria-vaccine/index.html
U.S. reports malaria vaccine breakthrough
By Matt Smith and William Hudson, CNN
August 8, 2013 -- Updated 1853 GMT (0253 HKT)
STORY HIGHLIGHTS
U.S. malaria study finds success with intravenous vaccine
The results are an advance but require more tests, experts say
Malaria sickens an estimated 200-million plus every year, killing about 1
million
(CNN) -- U.S. researchers say they've successfully tested a vaccine for malaria
on a small group of volunteers and hope to conduct large-scale tests soon.
The vaccine involves multiple, intravenous injections of a weakened form of the
disease, scientists from the National Institutes of Health, the Navy, Army and
other organizations reported Thursday. Though the results were promising, more
extensive field testing will be required, the researchers wrote.
The mosquito-borne tropical disease kills about 1 million people a year and
sickens more than 200 million. Dr. William Schaffner, head of the preventive
medicine department at Vanderbilt University's medical school, called the
results "a scientific advance" -- but it may be eight to 10 years before the
vaccine can be scientifically proven, approved and distributed.
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"This is not a vaccine that's ready for travelers to the developing world
anytime soon," Schaffner told CNN. "However, from the point of view of science
dealing with one of the big three infectious causes of death around the world,
it's a notable advance. And everybody will be holding their breath, watching to
see whether this next trial works and how well it works."
The findings were published Thursday by the peer-reviewed journal Science. The
trials involved 57 subjects, including 40 who received the vaccine, between
October 2011 to October 2012.
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Researchers reported that the six volunteers who received five intravenous
doses of the vaccine did not contract malaria when exposed to the microscopic
parasite. Of the nine who received four doses, three contracted the disease.
Schaffner, who was not part of the study, said previous attempts using
injections into skin or muscle didn't work. Multiple, intravenous injections
are "a heck of a way" to administer a vaccine, but "desperate times call for
desperate measures," he said.
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