Health Contents: Background Briefings | Medical notes | 
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BBC News Online: Health 

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---------- Wednesday, 19 December, 2001, 19:00 GMT Why red wine is
healthier



Red wine - packed full of goodness?

Scientists may have discovered the reason why red wine appears to
protect the heart. Numerous studies have suggested that moderate
alcohol drinking helps to reduce the likelihood of heart disease. 

The so-called "Mediterranean diet", which includes a larger intake of
wine, has been credited with lower rates of heart disease in those
countries, despite a higher intake of saturated fats. 

However, there is no clear evidence that red wine is any better than
any other alcoholic drink. 

But a team of scientists from Barts and the London School of 
Medicine, and the Queen Mary University in London, may have found a
mechanism which points to the benefits of red wine. 

They say it appears to interfere with the production of a body 
chemical which is vital to the process which clogs up arteries and
increases the risk of a heart attack. 

Wines tested 

That chemical, a protein called endothelin-1 (ET-1), has already been
shown to be involved in the formation of early signs of artery
disease, such as the formation of fatty streaks on the walls of
arteries. 

Chemicals which work against it have been shown to reduce the rate of
heart attacks in people who have heart disease. 

The London team tested extracts from 23 red wines, four white wines, a
rosé wine and one red non-alcoholic grape juice sample, after finding
that certain chemicals - called polyphenols - from Cabernet Sauvignon
grapes decreased the manufacture of ET-1 in bovine artery wall cells. 

They found that, in the red wines, the amount they inhibited ET-1 ran
parallel with the amount of these polyphenols they contained. 

The white and rosé wines had no similar effect. 

Cabernet the best 

Dr Roger Corder, from the William Harvey Research Institute at St
Barts, said: "What we are proposing is the mechanism that could
explain why red wine is a better alcoholic beverage to consume than
others. 

"If you consume one glass of red wine and you have a good absorption
of the active principle, that would be more than adequate." 

He said that Cabernet Sauvignon-derived wines seemed to have the most
impact. 

The study is published in the journal Nature. 


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---------- Related to this story: Apple juice 'protects the heart' (21
Feb 01 | Health) Apples and tomatoes 'good for lungs' (22 May 01 |
Health) 'Don't prescribe wine for heart disease' (23 Jan 01 | Health)
Psychologist staged pub therapy (12 Apr 01 | Health) 


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