Orang kafir lagi yang sibuk bikin penelitian tentang flu burung...
Dan bukan orang Islam Indoneisa - yang juga banyak jadi korban flu burung.
Habis orang Islam Indonesia lebih senang menghabiskan uangnya untuk naik haji
buat lari-lari kayak anjing kebeletberak di Makkah, muter-muter mengelilingi
Kaabah kayak burung penguin kepanasan, melempar batu kayak orang gila di Padang
Pasir...
Islam itu, saya bilang, sekarang ini, adalah ikon kedungan dan kenistaan.
----
Web address:
http://www.sciencedaily.com/releases/2008/07/
080715125926.htm
Newly Described 'Dragon' Protein Could Be Key To Bird Flu Cure
enlarge
The overall structure of the PAC --PB1 N complex. The structure is colored
according to secondary structure and elements are labeled. Helices are shown as
cylinders and are red in the brain domain and blue in the mouth domain; strands
are yellow and loops are green. The PB1 N peptide is magenta. (Credit: Image
courtesy of DOE/Argonne National Laboratory)
ScienceDaily (July 16, 2008) — Scientists and researchers have taken a big step
closer to a cure for the most common strain of avian influenza, or "bird flu,"
the potential pandemic that has claimed more than 200 lives and infected nearly
400 people in 14 countries since it was identified in 2003.
Researchers at the U.S. Department of Energy's (DOE) Argonne National
Laboratory, in conjunction with scientists from China and Singapore, have
crystallized and characterized the structure of one of the most important
protein complexes of the H5N1 virus, the most common strain of bird flu.
All viruses, including H5N1, contain only a small number of proteins that
govern all of the viruses' functions. In H5N1, perhaps the most important of
these proteins is RNA polymerase, which contains the instructions that allows
the virus to copy itself along with all of its genetic material. The Argonne
study focused on H5N1's RNA polymerase protein, which contains three subunits:
PA, PB1 and PB2.
After performing X-ray crystallography on the protein crystals at Argonne's
Structural Biology Center 19ID beamline at the Advanced Photon Source, the
researchers saw a surprising resemblance in the protein structure's image.
"When we mapped out the PA subunit, it looked very much like the head of a
dragon," said Argonne biophysicist Andrzej Joachimiak. "One domain looked like
the dragon's brains, and the other looked like its mouth."
During RNA replication -- the phase during which the virus "reproduces" -- all
three of the subunits of the protein assemble themselves in a particular
configuration. In order for this congregation to take place, the researchers
determined the end of the PB1 subunit has to insert itself and bind to the
"dragon's mouth" part of the PA subunit.
This unexpected relationship between the two subunits could inspire a number of
different therapies or vaccines for H5N1 that rely on muzzling the "dragon's"
jaws with another molecule or chemical compound that would block the PB1
subunit's access to the PA site, according to Joachimiak. "If we can put a bit
in the dragon's mouth, we can slow or even potentially someday stop the spread
of avian flu," he said. "Since we are talking about a relatively small protein
surface area, finding a way to inhibit RNA replication in H5N1 seems very
feasible."
Joachimiak hopes to more precisely identify the types of compounds that could
inhibit RNA replication in H5N1 by looking at the atomic-level grooves and
pockets within the PA "mouth" region. According to Joachimiak, scientists must
gain a more thorough understanding of the geometry of that small region in
order to effectively synthesize drugs that could prevent the further spread of
bird flu.
Argonne researchers Joachimiak and Rongguang Zhang collaborated with Zihe Rao
and Yingfang Liu, both members of the Institute of Biophysics of Chinese
Academy of Sciences. Rao is one of the most influential Chinese
crystallographers and biophysicists, Joachimiak said. The protein samples were
manufactured in China and crystals were shipped to Argonne for data collection
and structural analysis.
The work was funded by the National Natural Science Foundation of China as well
as the Chinese Ministry of Science and Technology and the U.S. Department of
Energy's Office of Biological and Environmental Research.
Journal reference:
1. He et al. Crystal structure of the polymerase PAC–PB1N complex from an
avian influenza H5N1 virus. Nature, 2008; DOI: 10.1038/nature07120
Adapted from materials provided by DOE/Argonne National Laboratory.
Need to cite this story in your essay, paper, or report? Use one of the
following formats:
APA
MLA
DOE/Argonne National Laboratory (2008, July 16). Newly Described 'Dragon'
Protein Could Be Key To Bird Flu Cure. ScienceDaily. Retrieved July 16, 2008,
from http://www.sciencedaily.com /releases/2008/07/080715125926.htm
---------------
Jusfiq Hadjar gelar Sutan Maradjo Lelo
Allah yang disembah orang Islam tipikal dan yang digambarkan oleh al-Mushaf itu
dungu, buas, kejam, keji, ganas, zalim lagi biadab hanyalah Allah fiktif.
__________________________________________________________
Not happy with your email address?.
Get the one you really want - millions of new email addresses available now at
Yahoo! http://uk.docs.yahoo.com/ymail/new.html
------------------------------------
Post message: [EMAIL PROTECTED]
Subscribe : [EMAIL PROTECTED]
Unsubscribe : [EMAIL PROTECTED]
List owner : [EMAIL PROTECTED]
Homepage : http://proletar.8m.com/Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/proletar/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/proletar/join
(Yahoo! ID required)
<*> To change settings via email:
mailto:[EMAIL PROTECTED]
mailto:[EMAIL PROTECTED]
<*> To unsubscribe from this group, send an email to:
[EMAIL PROTECTED]
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/
