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http://www.sciencedaily.com/releases/2009/12/
091222105219.htm
Calorie Restriction: Scientists Take Important Step Toward 'Fountain of Youth'
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Glucose molecular model. (Credit: iStockphoto/Martin McCarthy)
ScienceDaily (Dec. 26, 2009) Going back for a second dessert after your
holiday meal might not be the best strategy for living a long, cancer-free life
say researchers from the University of Alabama at Birmingham. That's because
they've shown exactly how restricted calorie diets -- specifically in the form
of restricted glucose -- help human cells live longer.
This discovery, published online in The FASEB Journal, could help lead to drugs
and treatments that slow human aging and prevent cancer.
"Our hope is that the discovery that reduced calories extends the lifespan of
normal human cells will lead to further discoveries of the causes for these
effects in different cell types and facilitate the development of novel
approaches to extend the lifespan of humans," said Trygve Tollefsbol, Ph.D., a
researcher involved in the work from the Center for Aging and Comprehensive
Cancer Center at the University of Alabama at Birmingham. "We would also hope
for these studies to lead to improved prevention of cancer as well as many
other age-related diseases through controlling calorie intake of specific cell
types."
To make this discovery, Tollefsbol and colleagues used normal human lung cells
and precancerous human lung cells that were at the beginning stages of cancer
formation. Both sets of cells were grown in the laboratory and received either
normal or reduced levels of glucose (sugar). As the cells grew over a period of
a few weeks, the researchers monitored their ability to divide, and kept track
of how many cells survived over this period.
They found that the normal cells lived longer, and many of the precancerous
cells died, when given less glucose. Gene activity was also measured under
these same conditions. The reduced glucose caused normal cells to have a higher
activity of the gene that dictates the level of telomerase, an enzyme that
extends their lifespan and lower activity of a gene (p16) that slows their
growth. Epigenetic effects (effects not due to gene mutations) were found to be
a major cause in changing the activity of these genes as they reacted to
decreased glucose levels.
"Western science is on the cusp of developing a pharmaceutical fountain of
youth" said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This
study confirms that we are on the path to persuading human cells to let us to
live longer, and perhaps cancer-free, lives."
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Story Source:
The above story is reprinted (with editorial adaptations by ScienceDaily
staff) from materials provided by Federation of American Societies for
Experimental Biology, via EurekAlert!, a service of AAAS.
Journal Reference:
1. Li et al. Glucose restriction can extend normal cell lifespan and impair
precancerous cell growth through epigenetic control of hTERT and p16
expression. The FASEB Journal, 2009; DOI: 10.1096/fj.09-149328
Need to cite this story in your essay, paper, or report? Use one of the
following formats:
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MLA
Federation of American Societies for Experimental Biology (2009, December 26).
Calorie restriction: Scientists take important step toward 'fountain of youth'.
ScienceDaily. Retrieved July 16, 2010, from http://www.sciencedaily.com
/releases/2009/12/091222105219.htm
Note: If no author is given, the source is cited instead.
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