http://www.smh.com.au/world/bodily-organs-overhauled-to-minimise-rejection-20101103-17e2k.html

Bodily organs overhauled to minimise rejection 

November 4, 2010 
MADRID: Spanish scientists have presented a new technique to create 
bioartificial organs for transplant using stem cells that they say will vastly 
reduce the risk of rejection of the donated organ.

The technique involved ''stripping'' a donated heart, liver or other organ that 
was deemed unsuitable for donation of their cells, leaving just a ''scaffold'', 
Francisco Fernandez-Aviles, the chief cardiologist at Gregorio Maranon 
Hospital, told a news conference. Stem cells from the patient would then be 
applied to this framework to regrow the organ, which would share their DNA, 
thus making it more acceptable to their body.

Doctors would be able to carry out transplants involving organs that had been 
regenerated using this technique in five years at the earliest, Dr 
Fernandez-Aviles said.

''This will put an end to two problems: the lack of donors or organs suitable 
for transplant and the rejection of transplanted organs by the patient,'' he 
said.

The hospital has eight heart ''scaffolds'' ready for use with this technique 
and it hopes to partially re-grow one heart using stem cells by the end of the 
year.

The Science Minister, Cristina Garmendia, said the hospital ''has the first lab 
in the world dedicated to producing bioartificial organs for transplant using 
adult stem cells.''

Three years ago the hospital became the first in the world to use stem cells 
from a patient's fat tissue, extracted through liposuction, to treat his heart.

Massive investment has been directed into stem-cell research, driven by hopes 
that immature, pre-cursor cells can be prompted into becoming specific adult 
cells for the heart, brain and so on.

Spain has become a world leader in organ donation since it set up a network of 
transplant co-ordinators in 1989 at all hospitals in the country.

They monitor emergency wards and tactfully talk to grieving families to get 
permission to use organs to save others.

About 15 per cent of families approached in Spain refused consent for organ 
donation, compared with the 40 per cent who refused in the 1980s before the 
system was set up.

Agence France-Presse 


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