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http://www.sciencedaily.com/releases/2011/01/
110107150600.htm
Grape Ingredient Resveratrol Increases Beneficial Fat Hormone
ScienceDaily (Jan. 7, 2011) Resveratrol, a compound in grapes, displays
antioxidant and other positive properties. In a study published this week,
researchers at the UT Health Science Center San Antonio describe a novel way in
which resveratrol exerts these beneficial health effects.
Resveratrol stimulates the expression of adiponectin, a hormone derived from
cells that manufacture and store fat, the team found. Adiponectin has a wide
range of beneficial effects on obesity-related medical complications, said
senior author Feng Liu, Ph.D., professor of pharmacology and member of the
Barshop Institute of Longevity and Aging Studies at the Health Science Center.
Both adiponectin and resveratrol display anti-obesity, anti-insulin resistance
and anti-aging properties.
"Results from these studies should be of interest to those who are obese,
diabetic and growing older," Dr. Liu said. "The findings should also provide
important information on the development of novel therapeutic drugs for the
treatment of these diseases."
The researchers confirmed the finding in cells and animal models. The study is
in the Jan. 7 issue of the Journal of Biological Chemistry.
Previous studies
In July 2009 in the journal Nature, the Barshop Institute and collaborators
reported that the compound rapamycin extended life in mice. Rapamycin, like
resveratrol, is under scrutiny for its beneficial health effects.
In 2010, Dr. Liu and colleagues announced that resveratrol inhibits activity of
the mammalian target of rapamycin (mTOR).
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Story Source:
The above story is reprinted (with editorial adaptations by ScienceDaily
staff) from materials provided by University of Texas Health Science Center at
San Antonio.
Journal Reference:
1. A. Wang, M. Liu, X. Liu, L. Q. Dong, R. D. Glickman, T. J. Slaga, Z.
Zhou, F. Liu. Up-regulation of Adiponectin by Resveratrol: THE ESSENTIAL ROLES
OF THE Akt/FOXO1 AND AMP-ACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND
DsbA-L. Journal of Biological Chemistry, 2010; 286 (1): 60 DOI:
10.1074/jbc.M110.188144
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University of Texas Health Science Center at San Antonio (2011, January 7).
Grape ingredient resveratrol increases beneficial fat hormone. ScienceDaily.
Retrieved January 10, 2011, from http://www.sciencedaily.com
/releases/2011/01/110107150600.htm
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of
ScienceDaily or its staff.
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