A little confirmation -- in my testing of proton engine send/receive clients I just now tested the performance of those clients built against Proton Release version, versus Proton RelWithDebInfo version.
I did indeed find that both versions were the same at running my tests, after averaging the speed of 5 tests with each version. In fact, RelWithDebInfo came in a mite faster -- a couple percent -- but probably still within the variability of the observations.