On 29 Mar 2009, at 16:48, Oliver Ruebenacker wrote:
    Hello Pat, All,
[snip]


 Perhaps the question should read: What would you advice to some one
who wants to build an ontology to describe pathways for Systems
Biology purposes?

My first advice would be to develop a clear set of requirements, perhaps in terms of the ASK/TELL paradigm, for the role of the ontology in typical Systems Biology applications you are trying to support.

Classic applications of (description logic based) ontologies include terminology development (e.g., see the caImages site), form management (see Galen), and data integration and navigation (see Tambis).

If your applications resemble these (or other standard applications) then it's easy to give a wealth of advice, methodologically and technically. If your application is radically different, then more work has to be done to understand the application requirements.

Cheers,
Bijan

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