Hi Andrea,
I'm also sorry for the late reply. My colleagues have been working on a
library of eligibility criteria to support the design of clinical trials
[1]. The criteria are now online in a triple store and visualised /
searchable [2].
Also, an article [3] has been published lately that analyses eligibility
criteria representation in industry-standard clinical trial protocols,
and the authors state that the criteria from clinicaltrials.gov (used in
most studies) differ from criteria in original full-text criteria.
I hope it helps!
Best,
Kathrin
[1] http://www.cs.vu.nl/~frankh/postscript/EKAW2012.pdf
[2] http://semweb.cs.vu.nl/eligibility
[3] http://www.sciencedirect.com/science/article/pii/S1532046413000762
Op 7/22/13 11:09 PM, Andrea Splendiani schreef:
HI,
thanks and sorry for the late reply. I have been doing a bit of reading.
Let's say I am up2date until more or less the date of your review (2007).
First, I wonder if something new come out since then (rather than evolutions of
approaches/standards already existing).
Second, I got the impression that rationales to standardize clinical trials
criteria vary a lot. Mining EHRs for candidates has different requirements from
criteria re-use, which in turns has different requirements from (trials)
discovery.
I was looking for some sampling of criteria in use in clinical trials. Could
not find anything (at least open). Does anybody have some pointer in this
direction ?
best,
Andrea
Il giorno 15/lug/2013, alle ore 07:21, Kathrin Dentler <k.dent...@vu.nl> ha
scritto:
Hi Andrea,
For a first broad overview, this paper is a good starting point:
Formal representation of eligibility criteria: A literature review
http://www.sciencedirect.com/science/article/pii/S1532046409001592
For CDISC, there is ongoing work on OWL/RDF formats:
http://www.cancer.gov/cancertopics/cancerlibrary/terminologyresources/cdisc
http://kerfors.blogspot.nl/2012/05/semantic-models-for-cdisc-based.html
Best,
Kathrin
Op 7/15/13 1:34 AM, Andrea Splendiani schreef:
Hi,
I was wondering if somebody could provide some pointer to work going on in an
area that is related to clinical trials: inclusion and exclusion criteria.
(I have followed the recent thread on encoding Hamilton Disease and pointers).
In, particular, I am interested in two things:
Standards with substantial uptake (sub question: is CDISC's uptake actual or
perspective ?).
Modeling of inclusion/exclusion criteria, but with a particular twist: not modeling the
questions, but the facts that are queried. Basically I am interested in modeling patients
and conditions (to the level of detail required "usually" required by clinical
trials). The subject itself can be very vast, but is there a framework which provides at
least an upper perspective on how to model subjects's features, diseases, interventions,
samples (also respect to time) ?
Any pointer is welcome!
best,
Andrea Splendiani
--
Kathrin Dentler
AI Department | Department of Medical Informatics
Faculty of Sciences | Academic Medical Center
Vrije Universiteit | Universiteit van Amsterdam
k.dent...@vu.nl | k.dent...@amc.uva.nl
http://www.few.vu.nl/~kdr250/
--
Kathrin Dentler
AI Department | Department of Medical Informatics
Faculty of Sciences | Academic Medical Center
Vrije Universiteit | Universiteit van Amsterdam
k.dent...@vu.nl | k.dent...@amc.uva.nl
http://www.few.vu.nl/~kdr250/
