Hi Paul,
I implemented the method I described for limiting the maximum number of 
files open at any time.  I have only performed very limited testing (on 
sacCer3 multiz7way MAF files), which simply showed that using this feature 
(by passing low value  maxOpenFiles2=5 to NLMSA constructor) yielded 
identical index files vs. the standard mode not applying this limit.

Maybe you could test this on your data.  You don't need to change anything 
in the parameters you pass to NLMSA construction, since its new default 
values should work OK for you:

* maxOpenFiles=1024 default is used only for requesting the OS to permit us 
to have up to 1024 open files;
* maxOpenFiles2=1000 default will limit readMAFfiles() to 1000 open files 
at any one time, which should work for you.

The code is available from my rebuf branch of my pygr repo on github:
https://github.com/cjlee112/pygr/tree/rebuf

Let me know whatever problems you run into...

Yours,

Chris

On Tuesday, April 30, 2013 12:38:05 PM UTC-7, Paul Rigor wrote:
>
> Hi Chris, thanks so much for taking care of this. Looking forward to 
> testing the feature. Cheers,
> Paul
>  

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