I got pyjamas desktop (using pythonwebkit) working fairly easily on my Gentoo system (well at least Hello.py in the examples/helloworld works fine with bin/pyjd). (On a completely different note, I cannot find an ebuild for python desktop on gentoo any more.)
Mac OS X is a different story. I still need to install some of the dependencies for pythonwebkit. It seems that I cannot install python GTK+ 2.24 without first installing GObjectIntrospection. I may have broken the linker on that system, as there are several packages for which the Xcode gcc still cannot symbols even though they are in the library it is trying to link. In short, getting pythonwebkit working on Mac OS X may take me some time.
