There are two ways to do this. Either start pymol from the command line in your working directory, or use .pymolrc to automatically change to this directory (something like os.chdir('~/working_directory') should do it).
Pete > Would it be possible to add setting to pymol for a default working directory? > Along with this, perhaps a setting that, by default, ignores hidden directories? As it now stands, whenever I fire up pymol on linux, I have > to > navigate down a huge list of hidden directories to find the directory, then > the subdirectory, within which my pdbs and pses reside. Pymol doesn't remember this so every time I start it, it is the same thing all over again. > Pete Meyer Fu Lab BMCB grad student Cornell University