Hi, I faced the same question some time ago for my PyQt application and decided that the distribution form that allows easiest deployment under Windows is a single file (the executable) with no installation.
The way I do that is basically creating my executable with Qt, PyQt, sip, python and my program linked statically. After compressing the executable with UPX, it has a size of about 3 MB, of which about 2.5-2.8 MB are due to the static libraries and the rest to my program proper. The downside of this approach is that the process to prepare the build environment is a bit long and not terribly simple, especially patching Python 2.5 and building a static python25.lib library. Of course, this only has to be done once. If you're insterested I can provide detailed information on how to achieve this. Regards, Miguel
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