Antoine Pitrou added the comment:
Indeed the function call cost actually dominates:
$ ./python -m timeit -s "a = 'hundred'" "a.find('x')"
1000000 loops, best of 3: 0.206 usec per loop
$ ./python -m timeit -s "a = 'hundred'; f=a.find" "f('x')"
10000000 loops, best of 3: 0.176 usec per loop
$ ./python -m timeit -s "a = 'hundred'" "'x' in a"
10000000 loops, best of 3: 0.0431 usec per loop
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<http://bugs.python.org/issue17170>
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