Yury Selivanov added the comment:

So... should we expose two keyword only parameters for 
Signature.from_callable() and signature():

- 'follow_wrapped=True' to follow __wrapped__ chains;
- 'keep_bound_arg=False' to skip/include first bound arg?

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue20691>
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