Serhiy Storchaka added the comment:

In about a half cases next_instr points to unaligned 16-bit value. Not all 
platforms allow access to unaligned data. We need other test in additional to 
PY_LITTLE_ENDIAN to allow this optimization.

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nosy: +mark.dickinson

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue25823>
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