R. David Murray added the comment:

For the record Zach's conclusion is that the conflict is a NppFTP issue, since 
api-ms-win-crt-runtime is part of the CRT and so any problem would not be 
unique to Python (or solvable by python).  The permissions issue is more 
obvious: that's how it is designed to work, and this is a documented change 
between python3.4 and python3.5, bringing it more in-line with how other 
Windows software works permissions-wise.

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nosy: +r.david.murray

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<http://bugs.python.org/issue25842>
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