Steve Dower added the comment:

VS 2015 won't cause this (I also work on that product as my day job, so I know 
exactly what it does and doesn't do), but the registry corruption probably did.

The pip support that's in the 2.7 installer is not the most robust code, and it 
can easily run into issues when your install is broken that make it fail. 
Repairing your prior install before uninstalling it is the easiest way to fix 
this in practically every case.

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<http://bugs.python.org/issue26183>
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