Gregory P. Smith added the comment:

Piping up from the peanut gallery here:

If your use case is not doing release builds for production use, i.e. "casual 
use", don't bother with either PGO or LTO.  It won't matter.

Your final build that you Q&A ship should absolutely use those. (nobody's going 
to disagree with that :)

While I would not reject changes that allow --with-lto to work in the absence 
of PGO, but I don't think it should be anyone's priority.

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<http://bugs.python.org/issue25702>
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