Nick Coghlan added the comment:
Virtual environments don't provide any sandboxing, they just let you isolate
different dependency sets from each other when switching between working on
different applications.
If you're inside a venv, you'll see either:
sys.prefix != sys.base_prefix (venv created by Py3 stdlib)
or:
hasattr(sys, "real_prefix") (venv created by virtualenv)
In this case, you can assume the user has write permissions to the virtual
environment and just invoke sys.executable with "-m pip install pipgui" as
arguments.
If you're *not* in a virtual environment, you're running directly in the system
Python, and the user may not have permission to install new packages for
everyone (and even if they do, it's not necessarily a good idea). In that case,
you want to pass "-m pip install --user pipgui", so the GUI components get
installed in the user's home directory, rather than system wide.
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<http://bugs.python.org/issue23551>
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