Serhiy Storchaka added the comment:

I see a tiny 3% regression.

$ ./python -m timeit -s 'import struct; u = struct.Struct("100000Q").unpack; b 
= b"abcd\0\0\0\0"*100000' 'u(b)'
Unpatched:  50 loops, best of 5: 9.34 msec per loop
Patched:    50 loops, best of 5: 9.66 msec per loop

$ ./python -m timeit -s 'import struct; u = struct.Struct("<100000Q").unpack; b 
= b"abcd\0\0\0\0"*100000' 'u(b)'
Unpatched:  50 loops, best of 5: 9.37 msec per loop
Patched:    50 loops, best of 5: 9.71 msec per loop

$ ./python -m timeit -s 'import struct; u = struct.Struct(">100000Q").unpack; b 
= b"\0\0\0\0dcba"*100000' 'u(b)'
Unpatched:  20 loops, best of 5: 11.6 msec per loop
Patched:    20 loops, best of 5: 12 msec per loop

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue30224>
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