Raymond Hettinger <raymond.hettin...@gmail.com> added the comment:

FWIW, I've had issues with environment variables in that they affect every 
version of Python running on a system and seem to defy isolation.  So, if one 
application needs the environment variable set, it will affect every 
application, even if it wants to keeps its contents private and not leak 
outside of a virtual environment.

Can your needs be met with just CLI flag rather than a system-wide environment 
variable?

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nosy: +rhettinger

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<https://bugs.python.org/issue33499>
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