Steve Dower <steve.do...@python.org> added the comment:

While you're working on these, the most important comparison to make is against 
the binaries from our 64-bit release. We've run PGO on those, and from the 
stats shown it optimises almost everything for size already. (You can enable 
the same profile by running "build.bat --pgo".)

For debug builds, I would prefer to optimise for (re)compile time. We can 
accept larger binaries in that case.

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<https://bugs.python.org/issue40151>
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