STINNER Victor <vstin...@python.org> added the comment:

We wrote an article about -fno-semantic-interposition flag that we use with GCC 
on RHEL8 and Fedora:
https://developers.redhat.com/blog/2020/06/25/red-hat-enterprise-linux-8-2-brings-faster-python-3-8-run-speeds/
"Enabling this flag disables semantic interposition, which can increase run 
speed by as much as 30%."

In short, the flag allows the compiler to inline code and so make further 
optimizations, when Python is built with --enable-shared.

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<https://bugs.python.org/issue38980>
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