STINNER Victor <vstin...@python.org> added the comment:

> Link Time Optimization (LTO) and Profile-Guided Optimization (PGO) have a 
> major impact on Python performance: they make Python between 10% and 30% 
> faster (coarse estimation).
>
> Currently, macOS installers distributed on python.org are built with Clang 
> 6.0 without LTO or PGO. I propose to enable LTO and PGO to make these 
> binaries faster.

Oh, I forgot to mention that I discovered that macOS doesn't use LTO when I 
worked on the https://bugs.python.org/issue39542#msg373230 issue.

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