STINNER Victor <vstin...@python.org> added the comment:

>_PyInterpreterState_GET():
>   mov    rax,QWORD PTR [rip+0x22a7dd]        # 0x743118 <_PyRuntime+568>
>   mov    rax,QWORD PTR [rax+0x10]

While working on bpo-39465, I wrote PR 20767 to optimize 
_PyInterpreterState_GET(): single instruction instead of two:

* Add _PyRuntimeState.interp_current member: atomic variable
* _PyThreadState_Swap() sets _PyRuntimeState.interp_current

But I failed to measure any performance difference.

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue40522>
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