Raymond Hettinger <raymond.hettin...@gmail.com> added the comment:

This may be a memory fragmentation problem and likely doesn't have anything to 
do with Queue instances.

As an experiment, try using queue.PriorityQueue and queue.LifoQueue to see if 
the issue persists.

----------
nosy: +rhettinger

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue43911>
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