Ned Deily <n...@python.org> added the comment:

Thanks for the report, Raymond, and for taking the time to check performance.

I am able to reliably reproduce the slowdowns in the benchmark between the 
3.10.0a7 and 3.10.0b1 versions provided by the macOS installers on python.org. 
A similar slowdown is seen on both Intel and Apple Silicon Macs running macOS 
11.3.1. Doing a quick build from source, I see no similar large differences 
between 3.10.0a7 and 3.10.0b1 on either macOS (with XC 12.5 Clang 12.0.5) or on 
a Debian Linux VM (with GCC 10.2.1). So it does seem to a difference in how the 
two macOS installers were built. There were some changes in the build env and 
process between a7 and b1. I will investigate further and report back here. 
But, the good news is that, AFAICT, there is no reason to suspect a general 
Python performance regression on this benchmark between a7 and b1.

----------
assignee:  -> ned.deily
priority: normal -> critical
title: Broad performance regression from 3.10a7 to 3.10b1 -> Broad performance 
regression from 3.10a7 to 3.10b1 with python.org macOS binaries

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<https://bugs.python.org/issue44037>
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