Ronald Oussoren <ronaldousso...@mac.com> added the comment:

The problem with moving from Catalina to Big Sur is a known issue, AFAIK 
there's an open issue for this.

The problem is that Big Sur moved system libraries into a big blob (which Apple 
calls the shared library cache). Ctypes uses an API that's new in macOS 11 to 
check if a library is in that cache, but only when compiled with the the macOS 
11 SDK or later as the API is not available in earlier SDKs.

Moving from Big Sur to earlier version should work fine, but only if you set 
the deployment target correctly during the build. This is how the "universal2" 
installers on python.org are build.

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue44689>
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