Serhiy Storchaka <storchaka+cpyt...@gmail.com> added the comment:

In the stdlib, there is only one use of to_bytes() with sys.byteorder (2 in 
tests), 16 uses of to_bytes()/from_bytes() with 'little' (22 in tests) and 22 
uses with 'big' (33 in tests). So making sys.byteorder the default will help 
almost nobody, and the advantage of 'big' over 'litte' is so small, that making 
any of them the default may only help in a half of cases and confuse in the 
other half.

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue45155>
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