So for the point of benchmarks, This is a link to some of the hacks developed 
by Pythonistas to boost some python speed. Among the hacks, there's a topics 
called "reducing dots" and "local variables".
https://wiki.python.org/moin/PythonSpeed/PerformanceTips

Also I would explain to a pythonista that an inline function is that function 
which is copied into the same spot that it's called.
I know it's a somewhat vague definition, but that's what I could think about so 
far.

By scope, yes, I do mean the function's local scope and not surrounding scope. 
And per example you've provided, yes, spam shall appear inside the functions a 
stated, and I think It might not appear in the global scope as hypothesized, 
since it's what we're trying to evade in the first place.

The rest of the concerns you've mentioned above are thinking points that I must 
take into consideration, that's exactly why I was poking around for such 
insights that I might have skipped while thinking about this.
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