akineko wrote:
Hello everyone,

I need to handle binary files that contain 64-bit (or 128-bit in the
furture) unsigned int data.
Python's array seems not supporting unsigned int type beyond 32-bit
('L').
I would like to use Python array as I need to make my program work on
both big-endian machines as well as on little-endian machines.

What is the best way to deal with 64-bit / 128-bit data elements in
Python (must support byteswap())?
(must be machine-independent)

You might give numpy a try. We support uint64 data even on 32-bit machines provided that your C compiler does. I haven't seen uint128 in the wild, though.

http://numpy.scipy.org/

--
Robert Kern

"I have come to believe that the whole world is an enigma, a harmless enigma
 that is made terrible by our own mad attempt to interpret it as though it had
 an underlying truth."
  -- Umberto Eco

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