You can use Wix setup from Beeware Briefcase project:

https://github.com/pybee/briefcase/blob/master/docs/background/getting-started.rst

And some discussion here:

https://github.com/pybee/briefcase/issues/30

On Tue, Mar 20, 2018, 8:40 AM Andrew Yang via PythonDotNet <
pythondotnet@python.org> wrote:

> Hi All,
>
> This might be a really dumb question, but I was wondering how can I create
> an installer for a C# wpf app, that uses pythonnet's Python.Runtime.dll?
>
> Currently, I've created a python module, imported the module in "using
> (Py.GIL())", and called some functions I've written. What methods are there
> to allow a user who does not have Python installed to be able to install
> and use my app (with or without having to install python)? I'm not sure if
> this is relevant, but I'm only importing from modules I've written or
> __builtin__ in the module used in my C# app.
>
> Additionally, is the Python.Runtime.dll that I build on my machine
> compatible with my users'?
>
> Best regards,
> Andrew
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