pyopencl ( http://mathema.tician.de/software/pyopencl ) seems to be the most mature and is very similar to PyCUDA which the same author wrote. It however requires boost; I haven't compiled it on OS X but I've compiled other projects that use boost and it can be a pain

Thats what I've installed in the end. Only problem was, as you said, boost which linked against the system python. I got competent help from the mailing list and now it works.

I haven't done any real work with it yet but it looks quite accesible.

Markus
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