Hi, I am from the homebrew team and passionate python lover. I can almost feel your pain :-)
Some things install nice with pip, but others don't. That is why I started to maintain a separate "tap" for additional homebrew python formulae like pillow, numpy, scipy, matplotlib, pygame ... (one can get these with `brew tap samueljohn/python` but in the future I want to move them to homebrew/science or so). These formulae re-use and depend on other software built with homebrew (for example suite-sparse from homebrew/science, libpng). See https://github.com/samueljohn/homebrew-python if you like. With our recent kickstarter supported Mac Minis, we plan to build and provide binary "bottles" for all our packages. Perhaps that is a good starting point? Basically one could make an installer that takes one or more bottles and installes them. Perhaps even automate to create these installers. Perhaps it's possible to transform our bottles into the wheel format (I have not looked into that). Homebrew works bests if installed at `/usr/local` because of the paths to other libs. Often rpath is enough to change that but some software has other means to "remember" and hard-code paths, so in general, we build the bottles in /usr/local and deploy them there, too. I'd love to team up and join forces. I am currently making Python 2.x and 3.x support in homebrew possible and simplifying how to install python software that provides a setup.py. bests, Samuel
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