I’ve found a solution. Adding the following entitlement during codesigning 
allows me to use ctypes:

   com.apple.security.cs.disable-executable-page-protection

That is a big relief.

Just

> On 14 Feb 2020, at 21:46, Just van Rossum <justvanros...@gmail.com> wrote:
> 
> Hello,
> 
> I’m trying to codesign and notarize my application, and thanks to the 
> following thread I’m getting closer:
> 
> https://mail.python.org/pipermail/pythonmac-sig/2018-October/024341.html
> 
> However, I’m stuck there, since my app _does_ require ctypes.
> 
> Is there currently a way to use ctypes in a py2app-built application, and 
> have it codesigned and notarized? I’m afraid the answer may be “no”, if I 
> read the thread correctly...
> 
> Thanks for any clues,
> 
> Just
> 

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