You mean mail *from* somebody, or mail *for* a local user?
For the first, either put the fellow's address in the badmailfrom
control file, or, if you do not want to produce any bounce, put
| if [ "$SENDER" = "[EMAIL PROTECTED]" ]; then exit 99; else exit 0; fi
./Mailbox
in your .qmail file (or `./Maildir, if you are using maildir).
Now if you want to reject mail for a certain local user (who exists!),
then you need to set up qmail-users, and then you can control the
user's mail via aliases (.qmail file).
Once qmail-users is set up, you can just set up an empty .qmail file
for the user in ~alias.
Mate