Recommended patches for high-volume ezmlm server

[Don Rose]

I am building a server to house several very high volume mailing lists
(2-4M users each) and wanted to know which patches were recommended for
use with ezmlm and ezmlm-idx, as well as qmail itself.

I have read about the big-concurrency patch and that seems relevant, but
I'm not sure about the others.

Can someone give me a heads up?  Thank you.