I guess that you destroy the accuracy of the calculation by the 
subtraction. Try
  2*(pnorm(8.104474,lower=FALSE))
instead, which results in
  5.29742e-16
for me.

Regards,
  Martin



jing hua zhao schrieb:
> Dear R list,
>
> I calculated a two-sided p values according to 2*(1-pnorm(8.104474)), which 
> gives  4.440892e-16. However, it appears to be  5.30E-16 by a colleague and 
> 5.2974E-16 from SAS. I tried to get around with mvtnorm package but it turns 
> out to be using pnorm for univariate case. I should have missed some earlier 
> discussions, but for the moment is there any short answer for a higher 
> precision? Somehow these days, statistical geneticists are infatuated with 
> such tiny p values!
>
> Many thanks in advance,
>
>
> Jing Hua
>
> _________________________________________________________________
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>
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>
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