Thanks for ur good advices. I've run Rprof and figured out that the bottleneck lies within the deviance function, which uses "integrate" to determine the deviance numerically. Since I'm not aware of a closed form solution for the integral

\int 1/(t^k*(1-t)^l) dt, \forall k,l \in R  ,

I've to rely on the numerical procedure. 'glm' itself is according to Rprof suprisingly not that time consuming and I could narrow the lack of performance down to multiple calls of the (numerically determined) deviance function, which is currently implemented by:

devf <- function(y, mu, ...) {
  mapply(function(y, mu, ...) {
    integrand <- function(u, y, ...)
      return((y - u) / varf(u, ...))
    int <- try(suppressWarnings(
      integrate(integrand, lower=y, upper=mu, y=y, ...)), silent=TRUE)
    if (class(int) == "try-error") {
      stop("Deviance could not be evaluated!\n", int)
    } else {
      return(-2 * int$value)
    }
  }, y, mu, ...)
}

where 'varf' denotes the particular variance function depending on some parameter vector.

I'd appreciate any comments on the code. Is it possible to speed up the computation?

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