assuming that the entries for each subject are ordered with respect to TIME and each subject has a measurement at TIME = 0, then you could use the following:

Data <- read.table(textConnection("ID  TIME    DV
1   0   0.880146038
1   1   0.88669051
1   3   0.610784702
1   5   0.756046666
2   0   0.456263368
2   1   0.369991537
2   3   0.508798346
2   5   0.441037014
3   0   0.854905349
3   1   0.960457553
3   3   0.609434409
3   5   0.655006334"), header = TRUE)
closeAllConnections()

Data$DVn <- with(Data, ave(DV, ID, FUN = function (x) x/x[1]))
Data

If either of the above assumptions doesn't hold, you'll have to tweak it.


I hope it helps.

Best,
Dimitris


On 6/20/2012 2:08 AM, york8866 wrote:
I have a dataframe such like the following:

ID      TIME    DV
1       0       0.880146038
1       1       0.88669051
1       3       0.610784702
1       5       0.756046666
2       0       0.456263368
2       1       0.369991537
2       3       0.508798346
2       5       0.441037014
3       0       0.854905349
3       1       0.960457553
3       3       0.609434409
3       5       0.655006334
.       .       .
.       .       .


I would like to generate another column with the normalized values of DV.
for each ID, normalize to the value at TIME 0.
I was able to use 2 loops to do the normalization, however, as 2 loops took
a long time for the calculation, I don't know whether there's a better way
to do it.
I have the following code with only 1 loop, but it did not work.  Can anyone
help with this? Thanks,

IDS <- unique(data.frame$ID)
for(WhichID in IDS)
{
subset <- data.frame[,"ID"] == WhichID
DVREAL <- data.frame[subset,"DV"]
DVNORM[WhichID] <- DVREAL/DVREAL[1]
}







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--
Dimitris Rizopoulos
Assistant Professor
Department of Biostatistics
Erasmus University Medical Center

Address: PO Box 2040, 3000 CA Rotterdam, the Netherlands
Tel: +31/(0)10/7043478
Fax: +31/(0)10/7043014
Web: http://www.erasmusmc.nl/biostatistiek/

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