Hi Srini, This is a statistics question, not a question about R, so this may not be the best place to ask. Try posting at http://stats.stackexchange.com/ or another statistics help list.
Best, Ista On Thu, Jan 31, 2013 at 11:11 PM, Srinivas Iyyer <[email protected]> wrote: > Hi: > Apologies for asking the following question. As this may sound very basic and > stupid for this forum , I honestly do not know how to solve it and I do not > have a teacher who can help me understand. > > I have list of genes (200) that are involved in a particular process and I > call this as a ProcSet. From an independent experiment I found that out of > 10,000 genes, 1500 are significant and I call these1500 genes as ResultSet. > > The intersection of ResultSet and ProcSet are 80 genes. > > That means 40% of ProcSet are significant. > > How do I calculate that 40% is significant and more than I expect by chance > given ResultSet and 10,000 genes I evaluated in the experiment. > > What I have: > n = 200 (ProcSet) > p = 0.4 > > N = 1500 (ResultSet) > > N1 =10,000 > > Pn = 0.15 > > What kind of test will help me know that 0.4 is significant given 0.15. Any > suggestions will greatly help me. > > Thank you. > Srini > > ______________________________________________ > [email protected] mailing list > https://stat.ethz.ch/mailman/listinfo/r-help > PLEASE do read the posting guide http://www.R-project.org/posting-guide.html > and provide commented, minimal, self-contained, reproducible code. ______________________________________________ [email protected] mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.
