I sending this again as I forgot to add a subject

Hello R-help
 
Does anyone know if there is a package for global 
fit analysis and if so how to use it.  I am trying to calculate the Kd 
value of a protein interacting with its ligand (When protein interacts 
with ligand this effect a number of residues). The table below 
shows with increasing concentration of ligand changes in three different
 residues.
 
Concentration  res1 res2  res3 
0 0 0  0 
1.99167E-05 0.012978 0.020862  0.03032 
3.95847E-05 0.019562 0.032288  0.048266 
7.82652E-05 0.021842 0.036  0.05521 
0.000115656 0.025274 0.043862  0.06398 
0.000151801 0.029896 0.048762  0.075302 
0.000186741 0.033544 0.053556  0.084334 
0.000220516 0.035676 0.058964 0.0914 
0.000274932 0.037834 0.061818  0.097096 
0.000352021 0.040694 0.066216  0.100024 
0.000422686 0.04329 0.070414  0.109974 
0.000552238 0.045482 0.074646  0.116072 
0.000777155 0.047062 0.07671  0.118722 
0.0012 0.05345 0.08602 0.130344 
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