Hi:
I am trying to identify mutually exclusive events from the following
example:
Cluster Gene Mutated not-mutated
1 G1 1 0
1 G2 1 0
1 G3 0 1
1 G4 0 1
1 G5 1 0
2 G1 0 1
2 G2 1 0
2 G3 1 0
2 G4 0 0
2 G5 1 0
In cluster 1 : G1, G2, G5 are mutated
In cluster 2: G2, G3, G5 are mutated.
I am interested in finding such G2-G5 event and G1-G3 events.
In total I have a 8 clusters and 150 gene (1200 rows x 4 columns).
What test could be appropriate to identify such pairs.
In my naive understanding would a fishers-exact test give such
combinations.
Thanks a lot.
-Adrian
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