Hello,  I am looking for a sample size function for samples sizes, to test 
proportions that are not binomial proportions.  The proportions represent a 
ratio of (final measure) / (baseline measure) on the same experimental unit.  
Searches using RSeek and such bring multiple hits for binomial proportions, but 
that doesn't seem to fit my situation.  Perhaps there's some standard 
terminology from a different field that would provide better hits than deeming 
this a 'rate' or a 'proportion'.

Of course, most sample size functions assume a normal distribution, while this 
data will be bounded between 0 and 1.  The scientist I'm working with feels 
it's important to make fair comparisons, any weight loss must account for the 
baseline weight.  A logistic transformation seems appropriate, but that term 
also didn't yield hits I recognized as useful.

Loss of weight --- compare treatments:
Treatment A:  1 - Final weight / Initial weight
Treatment B:  1 - Final weight / Initial weight

This appears to be a situation that would be common, but I'm not framing it in 
a way that matches an R package.  Any guidance is appreciated.

Regards, Paul


Paul Prew   ▪  Statistician
651-795-5942   ▪   fax 651-204-7504 
Ecolab Research Center   ▪  Mail Stop ESC-F4412-A 
655 Lone Oak Drive   ▪   Eagan, MN 55121-1560 



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