Dear all, I have a question on the dose-response estimation with clustered/ correlated binary data. I would like to estimate the hit rate for a certain test at various concentration levels. The test is used on 5 subjects, and each subject is tested 20 times. If we assume that the 100 samples are independent, the hit rate estimate is unbiased, but the variance is under-estimated. The other estimate of interest is the concentration that will give a 95% sensitivity of the test. I suppose the same problem would occur if a probit model is fitted to the data and assume all the samples are independent. Does anyone have any suggestions on how to analyze this kind of data?
Thanks a lot in advance. - Jacqueline ______________________________________________ [EMAIL PROTECTED] mailing list https://www.stat.math.ethz.ch/mailman/listinfo/r-help
