Hi Doug and Spencer,
 
Many thanks - Excellent!
 
All worked out nicely ....
 
Regards
 
Stephen

________________________________

From: Spencer Graves [mailto:[EMAIL PROTECTED]
Sent: Mon 20/06/2005 17:54
To: Stephen
Cc: [email protected]
Subject: Re: [R] Mixed model



(comments in line)

Stephen wrote:
> Dear Fellow R users,
>
> 
>
> I am fairly new to R and am currently conducting a mixed model.
>
> 
>
> I have 7 repeated measures on a simulated clinical trial
>
> 
>
> If I understand the model correctly, the outcome is the measure (as a
> factor) the predictors are clinical group and trial (1-7). The fixed
> factors are the measure and group. The random factors are the
intercept
> and id and group.
>
> 
>
> Based on this
>
> Dataset <- read.table("C:/Program
Files/R/rw2010/data/miss/model1.dat",
> header=TRUE, sep="\t", na.strings="NA", dec=".", strip.white=TRUE)
>
> require (nlme)
>
> model.mix <- lme (trans1 ~ Index1 + grp,
>                   random = ~ constant | id / grp ,
>                   data = Dataset,
>                   na.action = "na.exclude")

          I'm not familiar with this syntax.  I would replace your
"random"
formula with "~1|id/grp".  Did you get sensible results from your
attempt to compute "model.mix"?  How do the results compare with the
results from replacing your "random" with "~1|id/grp"?  Also, I'd try
the same thing with lmer;  please see "Fitting Linear Mixed Models in R"
by Doug Bates in the latest R News, downloadable from
"www.r-project.org" -> Newsletter.
>
> 
>
> # where trans1 is the factor of the repeated measures of the scale.
>
> # Index is the trial number, grp the group, and id the subject number.
>
> 
>
> I would like to split the results, just like SPSS splitfile by a
> variable in the Dataset called runnb
>
> I have tried using:
>
> 
>
>       by (Dataset, runnb,
>
>             function (x) (lme (trans1 ~ Index1 + grp,
>
>             random = ~ constant | id / grp ,
>
>             data = Dataset,
>
>             na.action = "na.exclude") )
>
> )
>
          I haven't used "by" enough to comment on this.  If I had
problems
with something like this, I might do something like the following:

          with(Dataset, table(runnb, id, grp))

          Do you have enough observations in all cells to be able to
estimate
all these individual models?  If yes, I might proceed as follows:

          b.lvls <- table(Dataset$runnb)
          nb <- length(b.lvls)
          fit <- vector(mode="list", nb)
          for(i in 1:nb)
                    fit[[i]] <- lme(...)       
       
          If I still had problems with this, I might manually step
through this
until I found the "i" that created the problem, etc.
> 
>
> but to no avail . as my computer hangs and I set my GUI to --mdi
> --max-mem-size=1200M.
>
> 
>
> Any ideas as to how to splitfile the results SPSS style would be most
> appreciated?
>
> 
>
> Also, does lme do pairwise deletion?
>
> 
>
> By the way
>
>
>>version
>
>
> platform i386-pc-mingw32
>
> arch     i386          
>
> os       mingw32       
>
> system   i386, mingw32 
>
> status                 
>
> major    2             
>
> minor    1.0           
>
> year     2005          
>
> month    04            
>
> day      18            
>
> language R   
>
> Windows XP Pro.
>
> 
>
> Many thanks
>
> Stephen
>
> Ps as its my first time on this group - neat program!
>
>
> ???? ?"? ???? ????
> http://mail.nana.co.il
>
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>
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