Since I've seen no reply to this so far, I will venture a few questions / suggestions. I have not used nlme (nor nln for Maggie Zhu), so I can not comment on the specifics. I have two general procedures for debugging when I get a cryptic error message.
First, in R, I can get the source just by entering the name of the function. I copy the results into a script file and trace the code line by line until I identify what crashes the code. Then I can work to identify what change I need to make, either to the code or prefereably to my argument(s), to make it work. Requestion "nlme" produces the following: > nlme function (model, data = sys.frame(sys.parent()), fixed, random = fixed, groups, start, correlation = NULL, weights = NULL, subset, method = c("ML", "REML"), na.action = na.fail, naPattern, control = list(), verbose = FALSE) { UseMethod("nlme") } This is not particularly helpful by itself. However, 'methods("nlme")' returns the following: [1] nlme.formula nlme.nlsList I can list these two functions [or access them via getAnywhere if the name is followed by an asterisk (*)] and get more detail. Second, with a complicated function call like the two nlme examples, I can try to delete or simplify arguments, e.g., delete terms from a formula, until I get something that either changes or eliminates the error message. Finally, "PLEASE do read the posting guide! http://www.R-project.org/posting-guide.html". It can help you formulate a question to increase the chances of a useful reply -- and you may even find the answer without waiting for someone on the list to reply. spencer graves [EMAIL PROTECTED] wrote: > This concerns the "Clinical Study of Quinidine" example on page 380 > of the book "Mixed-Effects Models in S and S-PLUS" by Pinheiro and Bates > (2000). > > I have tried to reproduce the example, but get an error: > > >>library(nlme) >>fm1Quin.nlme <- nlme(conc ~ quinModel(Subject, time, conc, dose, interval, lV, > > lKa, lCl), > + data=Quinidine, > + fixed=lV + lKa + lCl ~ 1, > + random=pdDiag(lV + lCl ~ 1), > + groups= ~ Subject, > + start=list(fixed=c(5, -0.3, 2)), > + na.action=na.pass, naPattern= ~ !is.na(conc)) > Error in solve.default(estimates[dimE[1] - (p:1), dimE[2] - (p:1), drop = > FALSE]) : > system is computationally singular: reciprocal condition number = > 6.61723e-17 > > Note: > - I am running R version 2.1.0 on Linux. > - The only difference between the code in the book and the code above is > that I use na.pass instead of na.include for the na.action argument, but > I don't think this is significant. > > I would appreciate help from anybody who has been able to get this example to > work. > > ______________________________________________ > R-help@stat.math.ethz.ch mailing list > https://stat.ethz.ch/mailman/listinfo/r-help > PLEASE do read the posting guide! http://www.R-project.org/posting-guide.html -- Spencer Graves, PhD Senior Development Engineer PDF Solutions, Inc. 333 West San Carlos Street Suite 700 San Jose, CA 95110, USA [EMAIL PROTECTED] www.pdf.com <http://www.pdf.com> Tel: 408-938-4420 Fax: 408-280-7915 ______________________________________________ R-help@stat.math.ethz.ch mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide! http://www.R-project.org/posting-guide.html